Semi-fluorinated alkanes for topical delivery of Cyclosporine
نویسندگان
چکیده
منابع مشابه
Impacts of Conformational Geometries in Fluorinated Alkanes
Research of blood substitute formulations and their base materials is of high scientific interest. Especially fluorinated microemulsions based on perfluorocarbons, with their interesting chemical properties, offer opportunities for applications in biomedicine and physical chemistry. In this work, carbon K-edge absorption spectra of liquid perfluoroalkanes and their parent hydrocarbons are prese...
متن کاملSemifluorinated alkanes as a liquid drug carrier system for topical ocular drug delivery.
Semifluorinated alkanes (SFA, e.g. perfluorobutylpentane F4H5, perfluorohexyloctane F6H8) are inert, non-toxic fluids capable of dissolving lipophilic drugs. The aim of this study to assess the bioavailability and safety of SFAs as drug solvents for the topical ocular application of Cyclosporin A (CsA). A commercially available CsA formulation (Restasis, 0.05% CsA in castor oil) was tested agai...
متن کاملassessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولCyclosporine Amicellar delivery system for dry eyes
BACKGROUND The objectives of this study were to develop stable cyclosporine A (CsA) ophthalmic micelle solutions for dry-eye syndrome and evaluate their physicochemical properties and therapeutic efficacy. MATERIALS AND METHODS CsA-micelle solutions (MS-CsA) were created by a simple method with Cremophor EL, ethanol, and phosphate buffer. We investigated the particle size, pH, and osmolarity....
متن کاملTopical cyclosporine inhibits mast cell-mediated conjunctivitis.
PURPOSE Allergic conjunctivitis is a common condition caused by a mast cell-mediated hypersensitivity reaction to immunoglobulin E-bound allergens. The purpose of this study was to investigate the effect of topical cyclosporine A on the development of mast cell-mediated conjunctivitis in mice. METHODS Allergic conjunctivitis was induced in C57BL/6 mice by topical applications of compound 48/8...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica
سال: 2016
ISSN: 1755-375X
DOI: 10.1111/j.1755-3768.2016.0686